H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis: Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response*

Abstract

Lymphocytic choriomeningitis virus (LCMV) and ectromelia virus-specific Tcell- mediated cytetoxicity was assayed in various strain combinations using as targets peritoneal macrophages which have been shown to express Ia antigens. Virus-specific cytotoxicity was found only in H-2K- or D-region compatible combinations. I-region compatibility was not necessary nor alone sufficient for lysis. Six different I-region specificities had no obvious effect on the capacity to generate in vivo specific cytotoxicity (expressed in vitro) associated with Dd. Low LCMV-specific cytotoxic activity generated in DBA/2 mice was caused by the non-H-2 genetic background. This trait was inversely related to the inf..