Journal article

H-2 COMPATIBILITY REQUIREMENT FOR VIRUS-SPECIFIC T-CELL-MEDIATED CYTOLYSIS - EVALUATION OF ROLE OF H-2I REGION AND NON-H-2 GENES IN REGULATING IMMUNE-RESPONSE

RM ZINKERNAGEL, MBC DUNLOP, RV BLANDEN, PC DOHERTY, DC SHREFFLER

JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 1976

Abstract

Lymphocytic choriomeningitis virus (LCMV) and ectromelia virus-specific T-cell-mediated cytotoxicity was assayed in various strain combinations using as targets peritoneal macrophages which have been shown to express Ia antigens. Virus-specific cytotoxicity was found only in H-2K- or D-region compatible combinations. I-region compatibility was not necessary nor alone sufficient for lysis. Six different I-region specificities had no obvious effect on the capacity to generate in vivo specific cytotoxicity (expressed in vitro) associated with Dd. Low LCMV-specific cytotoxic activity generated in DBA/2 mice was caused by the non-H-2 genetic background. This trait was inversely related to the inf..

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University of Melbourne Researchers