Journal article

ANGIOTENSIN-II RECEPTORS IN THE KIDNEY

FAO MENDELSOHN, M DUNBAR, A ALLEN, ST CHOU, MA MILLAN, G AGUILERA, KJ CATT

FEDERATION PROCEEDINGS | FEDERATION AMER SOC EXP BIOL | Published : 1986

Abstract

Angiotensin II (AngII) receptors have been localized in rat kidney by using the high-affinity agonist analog 125I-labeled [Sar1]AngII as a probe for in vitro autoradiography. Receptors were associated with four morphologically distinct patterns of distribution. First, a high density of receptors occurs in glomeruli. These are diffusely distributed, consistent with a mesangial localization. AngII receptor density shows a cortical gradient, which is highest in superficial and midcortical glomeruli and lowest in juxtamedullary glomeruli. Receptors associated with both superficial and deep glomeruli show down-regulation during low-sodium intake. Second, low levels of tubular AngII binding were s..

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University of Melbourne Researchers