Journal article

Effector CD4( ) and CD8( ) T-cell mechanisms in the control of respiratory virus infections

PC Doherty, DJ Topham, RA Tripp, RD Cardin, JW Brooks, PG Stevenson

Immunological Reviews | WILEY-BLACKWELL | Published : 1997


The rules for T-cell-mediated control of viruses that infect via the respiratory mucosae show both common themes and differences, depending on the nature of the pathogen. Virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are the key effectors of virus clearance in mice infected with both negative strand RNA viruses (influenza and Sendai) and a DNA virus, the murine gamma-herpesvirus-68 (MHV-68). Recently completed experiments establish that these activated CD8+ T cells indeed operate primarily via contact-dependent lysis. Perforin-mediated cytotoxicity seems to be the preferred mode, though a Fas-based mechanism can apparently serve as an alternative mechanism. Immune CD4+ T cells functioni..

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University of Melbourne Researchers