Journal article

Immune CD4( ) T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium

DJ Topham, RA Tripp, SR Sarawar, MY Sangster, PC Doherty

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 1996

Abstract

The experiments described establish that CD4+ T-cell-dependent effector mechanisms can eliminate an H3N2 influenza A virus from lung cells that are unable to express class II major histocompatibility complex (MHC) glycoproteins. Radiation chimeras were made by using CD4+ T cells and bone marrow from CD8-depleted, MHC class II +/+ mice and irradiated (950 rads) MHC class II -/- recipients. The influenza virus-specific CD4+ T-cell responses in these +/+-->-/- mice were not obviously different from those in the +/+-->+/+ controls: the cytokine profiles, the spectra of plasma cells producing the various immunoglobulin isotypes, and the frequencies of virus-specific CD4+ T cells were similar for ..

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University of Melbourne Researchers