Journal article

HOST RESPONSE TO SENDAI VIRUS IN MICE LACKING CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX GLYCOPROTEINS

S HOU, XY MO, L HYLAND, PC DOHERTY

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 1995

Abstract

The development of Sendai virus-specific cytotoxic T-lymphocyte (CTL) effectors and precursors (CTLp) has been compared for mice that are homozygous (-/-) for a disruption of the H-2I-Ab class II major histocompatibility complex glycoprotein and for normal (+/+) controls. The generation of CD8+ CTLp was not diminished in the -/- mice, though they failed to make virus-specific immunoglobulin G class antibodies. While the cellularity of the regional lymph nodes was decreased, the inflammatory process assayed by bronchoalveolar lavage (BAL) of the pneumonic lung was not modified, and potent CTL effectors were present in BAL populations recovered from both groups at day 10 after infection. There..

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University of Melbourne Researchers