Journal article

PARTITIONING OF RESPONDER CD8( ) T-CELLS IN LYMPH-NODE AND LUNG OF MICE WITH SENDAI VIRUS PNEUMONIA BY LECAM-1 AND CD45RB PHENOTYPE

S HOU, PC DOHERTY

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 1993

Abstract

Patterns of LECAM-1 and CD45RB expression have been analysed for mediastinal lymph node (MLN) and bronchoalveolar lavage (BAL) populations from C57BL/6J mice with primary Sendai virus pneumonia. The findings indicate that virus-specific CD8+ CTL precursors differentiate in the regional lymph node and become effector CTL after localization to the virus-infected respiratory tract. Relatively few of the MLN CD8+ T cells were LECAM-1-, and all were CD45RB-hi throughout the acute and recovery phases of this disease process. The CD8+ CD45RB-hi and LECAM-1+ T cells characteristic of the MLN were more apparent in the BAL during the 1st wk after exposure to virus, with this shifting to a predominant ..

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University of Melbourne Researchers