Journal article

DIVERGENCE BETWEEN CYTOTOXIC EFFECTOR FUNCTION AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION FOR INFLAMMATORY CD4 T-CELLS FROM MICE WITH SENDAI VIRUS PNEUMONIA

S HOU, M FISHMAN, KG MURTI, PC DOHERTY

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 1993

Abstract

Sendai virus pneumonia in beta 2-microglobulin-deficient [beta 2-m(-/-)] mice lacking CD8+ T cells is characterized by the development of CD4+ cytotoxic T lymphocytes that can be recovered directly from the respiratory tract. These CD4+ cytotoxic T lymphocytes are not found in beta 2-m (+/+) mice, though inflammatory CD4+ T cells from both beta 2-m (-/-) and beta 2-m (+/+) mice produce substantial amounts of tumor necrosis factor alpha. Blocking experiments with a monoclonal antibody that also inhibits tumor necrosis factor beta show that the secreted forms of these two cytokines are not responsible for virus-specific killing of class II major histocompatibility complex-compatible targets. C..

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University of Melbourne Researchers