Journal article

IMMUNOGENETIC ANALYSIS OF CELLULAR INTERACTIONS GOVERNING THE RECRUITMENT OF LYMPHOCYTES-T AND MONOCYTES IN LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INDUCED IMMUNOPATHOLOGY

PC DOHERTY, R CEREDIG, JE ALLAN

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 1988

Abstract

The Lyt2+ class I major histocompatibility complex (MHC)-restricted virus-immune T cells that induce murine lymphocytic choriomeningitis (LCM) are targeted onto radiation-resistant cells in the central nervous system of virus-infected mice. The use of appropriate bone marrow radiation chimeras as LCM virus-infected, (immunosuppressed recipients for immune T-cell transfer has established that, though bone marrow-derived cells can stimulate virus-specific cytotoxic T lymphocytes (CTL) in spleen, they do not reconstitute the barrier to T-cell recruitment from blood to cerebrospinal fluid. This is true for chimeras made up to 8 months previously, even though the inflammatory monocytes and macrop..

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University of Melbourne Researchers