Journal article

HYBRID RESISTANCE MODULATES THE INFLAMMATORY PROCESS INDUCED BY LYMPHOCYTIC CHORIOMENINGITIS VIRUS-IMMUNE T-CELLS

PC DOHERTY, JE ALLAN

IMMUNOLOGY | BLACKWELL SCIENCE LTD | Published : 1986

Abstract

The magnitude of the meningitis occurring 72 hr after adoptive transfer of 8-day lymphocytic choriomeningitis (LCMV)-immune effector T cells from cyclophosphamide-treated or untreated donors into cyclophosphamide-suppressed, LCMV-infected recipients is modified by the hybrid histocompatibility (Hh) effect. Evidence of inhibition in (H-2Kd Dd X H-2Kb Db)F1, as compared with H-2Kb Db, recipient mice is found for H-2Kd Db, H-2Kd Db and (H-2Kk Db X H-2Kb Db)F1, but not for (H-2Kk Dk X H-2Kb Db)F1 or H-2Kb Dd, LCMV-immune donor populations. The effect is cell dose-dependent, and the inflammatory process is 2.5-10 times lower in F1 than in recipient mice of parental type. These data indicate that ..

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University of Melbourne Researchers