Role of the major histocompatibility complex in targeting effector T cells into a site of virus infection

Abstract

Bone marrow radiation chimeras have been used as virus‐infected, cyclophosphamide‐suppressed recipients to analyze the major histocompatibility complex (MHC) restriction constraints on the adoptive transfer of lymphocytic choriomeningitis by immune T cells. The basic protocol employed [(A × B)F1→(A × C)F1] chimeras, where A, B, C are different MHC haplotypes, and the establishment of appropriate chimerism was measured by the capacity of, for instance, the transferred A, T cells to generate MHC‐restricted, virus‐specific cytotoxic T lymphocytes (CTL) in the spleen of the [(A × B)F1 →(B × C)F1] recipients. The experiments show quite clearly that maximal inflammatory process is only induced whe..