Journal article

ROLE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN TARGETING EFFECTOR T-CELLS INTO A SITE OF VIRUS-INFECTION

PC DOHERTY, JE ALLAN

EUROPEAN JOURNAL OF IMMUNOLOGY | VCH PUBLISHERS INC | Published : 1986

Abstract

Bone marrow radiation chimeras have been used as virus-infected, cyclophosphamide-suppressed recipients to analyze the major histocompatibility complex (MHC) restriction constraints on the adoptive transfer of lymphocytic choriomeningitis by immune T cells. The basic protocol employed [(A X B)F1----(A X C)F1] chimeras, where A, B, C are different MHC haplotypes, and the establishment of appropriate chimerism was measured by the capacity of, for instance, the transferred A, T cells to generate MHC-restricted, virus-specific cytotoxic T lymphocytes (CTL) in the spleen of the [(A X B)F1----(B X C)F1] recipients. The experiments show quite clearly that maximal inflammatory process is only induce..

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