Journal article

EARLY DOMINANCE OF IRRADIATED HOST-CELLS IN THE RESPONDER PROFILES OF THYMOCYTES FROM P-]F1 RADIATION CHIMERAS

R KORNGOLD, JR BENNINK, PC DOHERTY

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 1981

Abstract

The number of cells in the thymus of [k leads to (b X k)F1] radiation (100 rad) chimeras increases approximately 10-fold between 7 and 14 days after reconstitution with bone marrow. At least 50% of the cells in thymus on day 14 are of host origin and respond to virus presented in the context of both H-2k and H-2b when primed in irradiated, virus-infected (b X k)F1 recipients. Strong CTL responses can be generated from thymocytes of donor origin on day 21. All evidence of a significant host thymocyte component has disappeared by day 28. The responsiveness of 14-day thymocytes is not abrogated by pretreatment of the mice used to make the chimeras with anti-thymocyte serum or by using doses of ..

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University of Melbourne Researchers