Cellular immune response in virus infections

Abstract

Two levels of specificity exist in the killing of virus infected target cells by immune effector T cells. One relates to the classic specificity for the virus, and the second involves the necessity for sharing expression of genes mapping in K and D but not I regions. Among the theories that could explain this is that of dual recognition with separate T‐cell receptors detecting H‐2 and viral antigen. Support for this possibility was provided by experimental influenza virus infection where evidence of specific recognition of viral products was obtained. Copyright © 1978 American College of Rheumatology