Specificity of virus immune effector T cells for H 2K or H 2D compatible interactions: implications for H antigen diversity

Abstract

This is a detailed review of the work by the authors and other investigators on genetically determined differences in T cell responsiveness in mice. The ectromelia, Sendai and lymphocytic choriomeningitis viruses have been used in the majority of experiments. The in vitro 51Cr release assays used have been shown quite rigorously to be measuring immune T cell function. The effector T cells in these virus diseases of mice are specific both for the infecting virus and for the H2 genes of the mouse strains used. Different clones of virus immune T cells are associated with each allele at H 2K or H 2D. Heterozygotes generate four clones of effector T cells, compared with two in homozygotes. This p..