Capacity of sensitized thymus derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H 2 gene complex

Abstract

Adoptive immunization of syngeneic, immunosuppressed recipients infected with lymphocytic choriomeningitis (LCM) virus causes fatal neurologic disease within 2 to 4 days of cell transfer, providing that donors are sampled when the in vitro 51Cr release assay shows maximal specific activity of sensitized thymus derived lymphocytes (T cells). Prior treatment of immune spleen cells with AKR anti theta ascitic fluid and complement causes total abrogation of this in vivo activity. Fatal neurologic disease is induced only when donor and recipient share at least one set of H 2 antigenic specificities. Parent → F1 and F1 → parent combinations are as effective as syngeneic systems, but mice given all..