Journal article

SPECIFICITY AND DEVELOPMENT OF CYTOTOXIC THYMUS-DERIVED LYMPHOCYTES IN LYMPHOCYTIC CHORIOMENINGITIS

PC DOHERTY, RM ZINKERNAGEL, IA RAMSHAW

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 1974

Abstract

Cytotoxic capacity of immune CBA/H spleen cells for monolayers of L cells infected with lymphocytic choriomeningitis (LCM) virus is abrogated by prior incubation with AKR anti theta ascitic fluid and complement, but is unaffected by treatment with anti mouse Ig serum and complement. Depletion of splenic macrophages, or addition of normal or activated (from listeria immune mice) peritoneal macrophages, does not significantly modify the activity of immune spleen cells. Cell mediated release of 51Cr from LCM infected targets may thus be attributed to thymus derived effector lymphocytes (T cells). Such T cells are specific insofar as they do not exhibit cytotoxic activity for monolayers infected..

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University of Melbourne Researchers