Quantitative studies of the growth and rejection of allogeneic tumour cells in mouse cerebrospinal fluid: elimination in the absence of H-2 differences

Abstract

Following intracerebral (i.c.) inoculation DBA/2 (H 2d) mastocytoma cells (P815) grow to concentrations of greater than 10,000/μl in cerebrospinal fluid (CSF) of H 2 compatible BALB/c mice, but are completely eliminated from 90% of such animals within 12 days. A similar pattern occurs in allogeneic C57B1 (H 2b) and random bred WEHI mice, whereas syngeneic DBA/2 mice die within 7 days from unrestricted tumour growth. Rejection in BALB/c mice is enhanced by prior exposure to the tumour, but is severely depressed by pretreatment with cyclophosphamide. Leucocytes responsible for eliminating the mastocytoma are apparently not active against sarcoma 180 cells injected simultaneously. Subsequent to..