Journal article

QUANTITATIVE STUDIES OF GROWTH AND REJECTION OF ALLOGENEIC TUMOR-CELLS IN MOUSE CEREBROSPINAL-FLUID - ELIMINATION IN ABSENCE OF H-2 DIFFERENCES

PC DOHERTY, RM ZINKERNAGEL

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | WILEY | Published : 1975

Abstract

Following intracerebral (i.c.) inoculation DBA/2 (H-2d) mastocytoma cells (P815) grow to concentrations of greater than 10,000/mul in cerebrospinal fluid (CSF) of H-2 compatible BALB/c mice, but are completely eliminated from 90% of such animals within 12 days. A similar pattern occurs in allogeneic C57BL (H-2b) and random-bred WEHI mice, whereas syngeneic DBA/2 mice die within 7 days from unrestricted tumour growth. Rejection in BALB/c mice is enhanced by prior exposure to the tumour, but is severely depressed by pretreatment with cyclophosphamide. Leucocytes responsible for eliminating the mastocytoma are apparently not active against sarcoma 180 cells injected simultaneously. Subsequent t..

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