Louping-ill encephalitis in C57 black mice

Abstract

Weaned C57 black mice developed marked neurological symptoms 8 days after intraperitoneal inoculation with high titres of louping-ill virus. The virus was first detected in nervous tissue on day 4 and replication thereafter proceeded at approximately equivalent rates in different regions of the central nervous system. There was no obvious preferential site of virus entry into the brain. Lesions of encephalitis were found in only 25 per cent, of mice with neurological signs. Histological changes were present in the brains of all i.c. inoculated C57 black mice with symptoms. © 1969.