Journal article
The threshold for autoimmune T cell killing is influenced by B7-1
J Allison, LA Stephens, TW Kay, C Kurts, WR Heath, JFAP Miller, MF Krummel
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 1998
Abstract
The concept that naive CD4+ and CD8+ T cells require co-stimulatory signals for activation and proliferation is well documented. Less clear is the need for co-stimulation during the effector phase of the T cell response. Here we examined the influence of B7-1 (CD80) during the effector phase of an autoimmune response to pancreatic islets using transgenic mouse lines which expressed B7-1 in either all or only some of their beta cells ("confluent" or "patchy" RIP-B7-1 mice). Transgenic expression of B7-1 in normal mouse islets that co-expressed the pro-inflammatory cytokine, IL-2, resulted in early spontaneous autoimmunity. Islets with IL-2 and "confluent" B7-1 expression were destroyed wherea..
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