Invariant NKT Cells: Regulation and Function during Viral Infection
Jennifer A Juno, Yoav Keynan, Keith R Fowke
PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2012
Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), express a highly restricted T cell receptor (TCR) and respond to CD1d-restricted lipid ligands. iNKT cells are now appreciated to play an important role in linking innate and adaptive immune responses and have been implicated in infectious disease, allergy, asthma, autoimmunity, and tumor surveillance. Advances in iNKT identification and purification have allowed for the detailed study of iNKT activity in both humans and mice during a variety of chronic and acute infections. Comparison of iNKT function between ..View full abstract
KRF is supported by the Canadian Institutes for Health Research (CIHR). JAJ is supported by the CIHR International Infectious Disease and Global Health Training Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.