A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
J Lajoie, J Juno, A Burgener, S Rahman, K Mogk, C Wachihi, J Mwanjewe, FA Plummer, J Kimani, TB Ball, KR Fowke
Mucosal Immunology | NATURE PUBLISHING GROUP | Published : 2012
The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model to identify the correlates of protection and to aid in microbicide development. A total of 22 cytokines/chemokines were analyzed at the systemic and mucosal compartments in 57 HESN, 51 HIV-1-negative, and 67 HIV-1-infected commercial sex workers from Nairobi, Kenya. HESN individuals had significantly lower expression of monokine induced by interferon-γ (MIG), interferon-γ-induced protein 10 (IP-10), and interleukin-1α (IL-1α) in their genital mucosa compared with controls. HE..View full abstract
Awarded by CIHR
Julie Lajoie holds a postdoctoral research award from the CIHR and is a trainee in the CIHR international infectious disease and global health training program (IID&GHTP). Jennifer Juno is funded by the IID&GHTP. Keith Fowke holds a Manitoba Research Chair from the Manitoba Health Research Council. This study was funded by the CIHR operating Grant MOP-86721. We appreciate the technical support of S. Ramdahin and C. Mesa. We thank Paul McLaren for help in performing principal component analysis. We are grateful to all the staff and clients of the Pumwani clinic and technicians at the Kenya AIDS Control Program at the University of Nairobi.