Journal article

The role of serotonin in respiratory function and dysfunction

Gerard Hilaire, Nicolas Voituron, Clement Menuet, Ronaldo M Ichiyama, Hari H Subramanian, Mathias Dutschmann

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | ELSEVIER SCIENCE BV | Published : 2010

Abstract

Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at diff..

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