Biosynthesis and Mass Spectrometric Imaging of Tolaasin, the Virulence Factor of Brown Blotch Mushroom Disease
Kirstin Scherlach, Gerald Lackner, Katharina Graupner, Sacha Pidot, Tom Bretschneider, Christian Hertweck
ChemBioChem | WILEY-V C H VERLAG GMBH | Published : 2013
Killing them softly. The molecular basis for the biosynthesis of tolaasin, the Pseudomonas tolaasii-derived causative agent of mushroom (Agaricus bisporus) soft rot, was revealed by genome mining and analysis of the NRPS genes. Production of the toxic lipopeptides during infection was confirmed by imaging mass spectrometry. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Financial support by the International Leibniz Research School (ILRS) and the Jena School for Microbial Communication (JSMC) is gratefully acknowledged.