Journal article
A genomic approach to the cryptic secondary metabolome of the anaerobic world
AC Letzel, SJ Pidot, C Hertweck
Natural Product Reports | ROYAL SOC CHEMISTRY | Published : 2013
DOI: 10.1039/c2np20103h
Abstract
Covering: up to September 2012. A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted. © 2013 The Royal Society of Chemistry.