Formation of a Dinuclear Copper(I) Complex from the Clostridium-Derived Antibiotic Closthioamide
Florian Kloss, Sacha Pidot, Helmar Goerls, Thorsten Friedrich, Christian Hertweck
Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2013
A metal chelator from the oxygen-free world: Multiple lines of experimental evidence show that closthioamide, the first antibiotic from a strictly anaerobic bacterium (Clostridium), is a selective copper(I) chelator. The geometry of the polythioamide complex, in which two copper ions in a trigonal-planar coordination stabilize the pitch of a helix-like arrangement, is unprecedented for natural products. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
We thank S. Behnken for initial biological studies, A. Perner for MS analyses, H. Heinecke for NMR measurements, Uwe Knupfer for support in fermentations, and Dr. T. Wichard (FSU) for initial UPLC method development. This work was supported by the "Pakt fur Forschung und Innovation" of the Free State of Thuringia and the Federal Ministry of Science and Technology (BMBF (Germany)), and the International Leibniz Research School for Biomolecular and Microbial Interactions (ILRS), as part of the excellence graduate school Jena School for Microbial Communication (JSMC).