Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Aysu Okbay; Bart ML Baselmans; Jan-Emmanuel De Neve; Patrick Turley; Michel G Nivard; Mark Alan Fontana; S Fleur W Meddens; Richard Karlsson Linner; Cornelius A Rietveld; Jaime Derringer; Jacob Gratten; James J Lee; Jimmy Z Liu; Ronald de Vlaming; Tarunveer S Ahluwalia; Jadwiga Buchwald; Alana Cavadino; Alexis C Frazier-Wood; Nicholas A Furlotte; Victoria Garfield; Marie Henrike Geisel; Juan R Gonzalez; Saskia Haitjema; Robert Karlsson; Sander W van der Laan; Karl-Heinz Ladwig; Jari Lahti; Sven J van der Lee; Penelope A Lind; Tian Liu; Lindsay Matteson; Evelin Mihailov; Michael B Miller; Camelia C Minica; Ilja M Nolte; Dennis Mook-Kanamori; Peter J van der Most; Christopher Oldmeadow; Yong Qian; Olli Raitakari; Rajesh Rawal; Anu Realo; Rico Rueedi; Borge Schmidt; Albert V Smith; Evie Stergiakouli; Toshiko Tanaka; Kent Taylor; Juho Wedenoja; Juergen Wellmann; Harm-Jan Westra; Sara M Willems; Wei Zhao; Najaf Amin; Andrew Bakshi; Patricia A Boyle; Samantha Cherney; Simon R Cox; Gail Davies; Oliver SP Davis; Jun Ding; Nese Direk; Peter Eibich; Rebecca T Emeny; Ghazaleh Fatemifar; Jessica D Faul; Luigi Ferrucci; Andreas Forstner; Christian Gieger; Richa Gupta; Tamara B Harris; Juliette M Harris; Elizabeth G Holliday; Jouke-Jan Hottenga; Philip L De Jager; Marika A Kaakinen; Eero Kajantie; Ville Karhunen; Ivana Kolcic; Meena Kumari; Lenore J Launer; Lude Franke; Ruifang Li-Gao; Marisa Koini; Anu Loukola; Pedro Marques-Vidal; Grant W Montgomery; Miriam A Mosing; Lavinia Paternoster; Alison Pattie; Katja E Petrovic; Laura Pulkki-Raback; Lydia Quaye; Katri Raikkonen; Igor Rudan; Rodney J Scott; Jennifer A Smith; Angelina R Sutin; Maciej Trzaskowski; Anna E Vinkhuyzen; Lei Yu; Delilah Zabaneh; John R Attia; David A Bennett; Klaus Berger; Lars Bertram; Dorret I Boomsma; Harold Snieder; Shun-Chiao Chang; Francesco Cucca; Ian J Deary; Cornelia M van Duijn; Johan G Eriksson; Ute Bultmann; Eco JC de Geus; Patrick JF Groenen; Vilmundur Gudnason; Torben Hansen; Catharine A Hartman; Claire MA Haworth; Caroline Hayward; Andrew C Heath; David A Hinds; Elina Hypponen; William G Iacono; Marjo-Riitta Jarvelin; Karl-Heinz Jockel; Jaakko Kaprio; Sharon LR Kardia; Liisa Keltikangas-Jarvinen; Peter Kraft; Laura D Kubzansky; Terho Lehtimaki; Patrik KE Magnusson; Nicholas G Martin; Matt Mcgue; Andres Metspalu; Melinda Mills; Renee de Mutsert; Albertine J Oldehinkel; Gerard Pasterkamp; Nancy L Pedersen; Robert Plomin; Ozren Polasek; Christine Power; Stephen S Rich; Frits R Rosendaal; Hester M den Ruijter; David Schlessinger; Helena Schmidt; Rauli Svento; Reinhold Schmidt; Behrooz Z Alizadeh; Thorkild IA Sorensen; Tim D Spector; Andrew Steptoe; Antonio Terracciano; A Roy Thurik; Nicholas J Timpson; Henning Tiemeier; Andre G Uitterlinden; Peter Vollenweider; Gert G Wagner; David R Weir; Jian Yang; Dalton C Conley; George Davey Smith; Albert Hofman; Magnus Johannesson; David I Laibson; Sarah E Medland; Michelle N Meyer; Joseph K Pickrell; Tonu Esko; Robert F Krueger; Jonathan P Beauchamp; Philipp D Koellinger; Daniel J Benjamin; Meike Bartels; David Cesarini

Journal article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Aysu Okbay, Bart ML Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linner, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James J Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/ng.3552

University of Melbourne Researchers

Miriam Mosing Author Melbourne School of Psychological Sciences

Grants

Awarded by Ragnar Soderberg Foundation

Awarded by Swedish Research Council

Awarded by ERC Consolidator Grant

Awarded by NIA/NIH

Awarded by Economic and Social Research Council

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Awarded by Novo Nordisk Fonden

Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Awarded by NATIONAL INSTITUTE ON AGING

Awarded by NATIONAL INSTITUTE ON DRUG ABUSE

Funding Acknowledgements

We are grateful to P.M. Visscher for advice, support, and feedback. We thank S. Cunningham and N. Galla for research assistance. This research was carried out under the auspices of the Social Science Genetic Association Consortium (SSGAC). The SSGAC seeks to facilitate studies that investigate the influence of genes on human behavior, well-being, and social-scientific outcomes using large GWAS meta-analyses. The SSGAC also provides opportunities for replication and promotes the collection of accurately measured, harmonized phenotypes across cohorts. The SSGAC operates as a working group within the CHARGE Consortium. This research has also been conducted using the UK Biobank Resource. The study was supported by funding from the US National Science Foundation (EAGER: 'Workshop for the Formation of a Social Science Genetic Association Consortium'), a supplementary grant from the National Institute of Health Office of Behavioral and Social Science Research, the Ragnar Soderberg Foundation (E9/11), the Swedish Research Council (421-2013-1061), the Jan Wallander and Tom Hedelius Foundation, an ERC Consolidator Grant (647648 EdGe), the Pershing Square Fund of the Foundations of Human Behavior, and the NIA/NIH through grants P01-AG005842, P01-AG005842-20S2, P30-AG012810, and T32-AG000186-23 to NBER and R01-AG042568-02 to the University of Southern California. A full list of acknowledgments is provided in the Supplementary Note.