Journal article

TWIN BIRTH IS NOT A RISK FACTOR FOR SEIZURES

SF BERKOVIC, RA HOWELL, DA HAY, JL HOPPER

NEUROLOGY | LITTLE BROWN CO | Published : 1993

Abstract

There is a belief that perinatal factors are a major cause of epilepsy. We studied a community-based sample of twins, a group with a marked excess of adverse perinatal events. The observed number of non-twin siblings with seizures did not differ from that predicted by the age-specific cumulative incidence rate of seizures (4.2% at age 10 years) in the twins. The types of epilepsies in the twins were largely benign and self-limited and not those associated with brain damage. Zygosity, birth order, and birth weight did not predict affected status. Within affected sibships, the frequency of seizures in co-twins of dizygotic probands (9%) was not different from the frequency in non-twin siblings..

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