Conference Proceedings

Partial Efficacy of a Broadly Neutralizing Antibody against Cell-associated SHIV Infection

Matthew Parsons, Sarah Lloyd, Robert Center, Katherine Swiderek, Celia LaBranche, David Montefiori, Brandon Keele, Jeffrey Lifson, Vanessa Venturi, Miles Davenport, Thakshila Amarasena, Stephen Kent

AIDS RESEARCH AND HUMAN RETROVIRUSES | MARY ANN LIEBERT, INC | Published : 2016

Abstract

Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human immunodeficiency virus (SHIV) challenge, but their efficacy against cell-associated SHIV is unclear. Virus in cell-associated format is highly infectious, present in transmission-competent bodily fluids, and potentially capable of evading antibody-mediated neutralization. The PGT121 BnAb, which recognizes an epitope consisting of the V3 loop and envelope glycans, mediates antibody-dependent cellular cytotoxicity and neutralization of cell-to-cell HIV-1 transmission. To evaluate whether a BnAb can prevent infection after cell-associated viral challenge, we infused pigtail macaques with PGT121 or an isotype co..

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