Conference Proceedings

Partial Efficacy of a Broadly Neutralizing Antibody against Cell-associated SHIV Infection

Matthew Parsons, Sarah Lloyd, Robert Center, Katherine Swiderek, Celia LaBranche, David Montefiori, Brandon Keele, Jeffrey Lifson, Vanessa Venturi, Miles Davenport, Thakshila Amarasena, Stephen Kent

Science Translational Medicine | MARY ANN LIEBERT, INC | Published : 2016

Abstract

Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human immunodeficiency virus (SHIV) challenge, but their efficacy against cell-associated SHIV is unclear. Virus in cell-associated format is highly infectious, present in transmission-competent bodily fluids, and potentially capable of evading antibody-mediated neutralization. The PGT121 BnAb, which recognizes an epitope consisting of the V3 loop and envelope glycans, mediates antibody-dependent cellular cytotoxicity and neutralization of cell-to-cell HIV-1 transmission. To evaluate whether a BnAb can prevent infection after cell-associated viral challenge, we infused pigtail macaques with PGT121 or an isotype co..

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