Journal article
Modulation of innate and adaptive cellular immunity relevant to HIV-1 vaccine design by seminal plasma
KJ Selva, SJ Kent, MS Parsons
AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Objectives: Mucosal exposure to HIV-1 infection generally occurs in the presence of semen. Immunomodulation by seminal plasma is well described in the reproductive biology literature. Little is known, however, about the impact of seminal plasma on innate and adaptive anti-HIV-1 cellular immunity. Design: The study investigated the effects of seminal plasma on immune responses considered important for prophylactic HIV-1 vaccine development, namely innate and adaptive cellular immunity mediated by natural killer (NK) cells and T cells, respectively. Methods: The ability of seminal plasma to modulate direct, antibody-dependent and cytokine-stimulated NK cell activation was assessed utilizing in..
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Funding Acknowledgements
We thank our collaborators Dr Kiat Ruxrungtham (Chulalongkorn University) for the HIV-1-infected seminal plasma samples and Dr Andrew Brooks (University of Melbourne) for the 721.221 and P815 cell lines. Funding from the Australian National Health and Medical Research Council (NHMRC) supported this research. M.S.P is supported by a fellowship from the Canadian Institutes for Health Research (CIHR).