Journal article

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

Ada WC Yan, Pengxing Cao, Jane M Heffernan, Jodie McVernon, Kylie M Quinn, Nicole L La Gruta, Karen L Laurie, James M McCaw



The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model ..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by Australian Research Council

Funding Acknowledgements

Ada W. C. Yan is supported by an Australian Postgraduate Award; Pengxing Cao is supported by a National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (1078068); Jane M. Heffernan is supported by the Natural Sciences and Engineering Research Council of Canada and the York Research Chair program; J. McVernon is supported by an NHMRC Career Development Fellowship (CDF1061321); Nicole L. LaGruta is a Sylvia and Charles Viertel Senior Medical Research Fellow and is funded by an NHMRC Program grant (AI1071916); James M. McCaw is supported by an Australian Research Council Future Fellowship (FT110100250). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.