Journal article
Sensory detection of threshold intensity resistive loads in severe obstructive sleep apnoea
WR Ruehland, PD Rochford, RJ Pierce, KE Webster, JA Trinder, AS Jordan, FJ O'Donoghue
Respiratory Physiology and Neurobiology | ELSEVIER SCIENCE BV | Published : 2017
Abstract
Respiratory related evoked potentials (RREPs) were used to investigate whether sensory detection of small mid-inspiratory resistive loads (≈1.2–6.2 cmH2O L−1 s), delivered during wakefulness, was impaired in obstructive sleep apnoea (OSA). It was reasoned that impaired detection of minor airway patency challenge may lead to difficult-to-remedy further collapse. There was a significant reduction in OSA (n = 16) vs. control (n = 17) participants in the slope of the relationship between the P1 RREP component amplitude, which reflects arrival of somatosensory information at the cortex, and stimulus intensity, expressed as change in epiglottic pressure (mean [95% confidence intervals]: −0.50 [−0...
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Awarded by Austin Medical Research Foundation
Funding Acknowledgements
This study was supported by research grants from the National Health and Medical Research Council of Australia (grant number 430302), Austin Medical Research Foundation, the Jack Brockhoff Foundation, and the Institute for Breathing and Sleep. Medical equipment for this study was supplied by ResMed Australia, Philips Respironics and Fisher and Paykel Healthcare. Funding and equipment sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.