Journal article
Nasal Resistance Is Elevated in People with Tetraplegia and Is Reduced by Topical Sympathomimetic Administration
L Gainche, DJ Berlowitz, M Leguen, WR Ruehland, FJ O'Donoghue, J Trinder, M Graco, R Schembri, DJ Eckert, PD Rochford, AS Jordan
Journal of Clinical Sleep Medicine | AMER ACAD SLEEP MEDICINE | Published : 2016
DOI: 10.5664/jcsm.6272
Abstract
Study Objectives: Obstructive sleep apnea (OSA) is common in individuals with tetraplegia and associated with adverse health outcomes. The causes of the high prevalence of OSA in this population are unknown, but it is important to understand as standard treatments are poorly tolerated in tetraplegia. Nasal congestion is common in tetraplegia, possibly because of unopposed parasympathetic activity. Further, nasal obstruction can induce OSA in healthy individuals. We therefore aimed to compare nasal resistance before and after topical administration of a sympathomimetic between 10 individuals with tetraplegia (T) and 9 able-bodied (AB) controls matched for OSA severity, gender, and age. Method..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Australian Research Council
Awarded by NHMRC RD Wright Fellowship
Funding Acknowledgements
This was not an industry supported study. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (APP1065913) and proudly supported by the Transport Accident Commission. Dr Jordan was supported by the Australian Research Council (FT100100203). Dr Eckert is supported by a NHMRC RD Wright Fellowship (1049814). This work was performed at The Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC Australia. Dr. Berlowitz has received research support from ResMed. Dr. Jordan has received the use of investigational devices or drugs from Philips Respironics. The other authors have indicated no financial conflicts of interest.