Journal article
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
EC Johnson, DW Bjelland, DP Howrigan, A Abdellaoui, G Breen, A Børglum, S Cichon, F Degenhardt, AJ Forstner, J Frank, G Genovese, S Heilmann-Heimbach, S Herms, P Hoffman, W Maier, M Mattheisen, D Morris, B Mowry, B Müller-Mhysok, B Neale Show all
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2016
Open access
Abstract
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7],..
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Awarded by Medical Research Council
Funding Acknowledgements
This study was supported by grants from the National Institutes of Health and the National Institute of Mental Health (grants K01MH085812 and R01MH100141 to MCK and MH085520 to the Psychiatric Genomics Consortium). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.