Journal article

C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis

Brisa S Fernandes, Johann Steiner, Marc L Molendijk, Seetal Dodd, Patricia Nardin, Carlos-Alberto Goncalves, Felice Jacka, Cristiano A Kohler, Chandan Karmakar, Andre F Carvalho, Michael Berk

The Lancet Psychiatry | ELSEVIER SCI LTD | Published : 2016

Abstract

BACKGROUND: Inflammatory processes and neural-immune interactions have been implicated in the pathogenesis of psychiatric conditions, but studies in bipolar disorder are inconclusive so far. We aimed to investigate whether peripheral concentrations of C-reactive protein (CRP), an acute-phase response protein of inflammatory activity, are increased in bipolar disorder across the mood spectrum. METHODS: In this systematic review and meta-analysis, we searched MEDLINE, the Cochrane Library, Scopus, and Web of Knowledge from database inception to Aug 14, 2016, for studies that measured serum and plasma CRP concentrations in adult patients with bipolar disorder (as defined by DSM-IV-TR) and healt..

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Grants

Awarded by CNPq, Brazil


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

We thank all authors of the papers included in our study, particularly Domenico De Berardis (Department of Neurosciences and Imaging, Chair of Psychiatry, University "G D'Annunzio" of Chieti, Chieti, Italy), Nilay Hepgul (King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK), Valeria Mondelli (King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK), and Jaana Suvisaari (Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland), who kindly provided us with unpublished data. BSF is supported by a postdoctoral scholarship and a research grant (MCTI/CNPQ/Universal 14/2014461833/2014-0) from CNPq, Brazil. CAK received a postdoctoral fellowship from CAPES, Brazil. AFC received a research fellowship from CNPq (Brazil, level II). MB is supported by a Senior Principal Research Fellowship 1059660 from the Australian National Health and Medical Research Council.