Journal article
Mitochondrial genomes of two Babesia taxa from sheep in China as a foundation for population genetic and epidemiological investigations
T Wang, G Guan, PK Korhonen, AV Koehler, ND Young, RS Hall, H Yin, RB Gasser
Infection Genetics and Evolution | ELSEVIER SCIENCE BV | Published : 2017
Abstract
Here, we sequenced, assembled and annotated the mitochondrial (mt) genomes of two operational taxonomic units of Babesia from sheep from China using a deep sequencing-coupled approach. Then, we defined and compared the gene order of these mt genomes (~ 5.8 to 6.2 kb in size), assessed sequence differences in mt genes among Babesia taxa and evaluated genetic relationships among these taxa and related apicomplexans (Theileria) for which mt genomic data sets were available. We also identified mt genetic regions that might be useful as markers for future population genetic and molecular epidemiological studies of Babesia from small ruminants. We propose that the sequencing-bioinformatic approach..
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Awarded by Alexander von Humboldt-Stiftung
Funding Acknowledgements
This project was partially funded by the PiroVac (KBBE-3-245145; H.Y.), National Natural Science Foundation of China (31072130; G.G.), ASTIP, FRIP (2014ZL010), Chinese Academy of Agricultural Sciences (H.Y.) and NBCIS (CARS-38; H.Y.) of China and the Australian Research Council (ARC) (R.B.G.); it was also supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant (VR0007; R.B.G.) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. Other support from the State Key Laboratory of Veterinary Etiological Biology Project, China (SKLVEB2008ZZKT019; H.Y.), the Australian Academy of Science, Alexander von Humboldt Foundation and Melbourne Water Corporation is gratefully acknowledged. N.D.Y. is an NHMRC Career Development Fellow (CDF).