Journal article
The evolving world of pseudoenzymes: Proteins, prejudice and zombies
PA Eyers, JM Murphy
BMC Biology | BIOMED CENTRAL LTD | Published : 2016
Abstract
Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.
Grants
Awarded by State Government of Victoria
Funding Acknowledgements
We acknowledge useful discussions with our 'pseudoenzyme' colleagues, especially those present at the Biochemical Society Pseudoenzymes 2016 meeting in Liverpool, which stimulated many of our ideas and were the inspiration for these Q&As. PAE acknowledges relevant support from The Royal Society, North West Cancer Research and a BBSRC tools and technology grant (BB/N021703/1). JMM thanks the National Medical Research Council of Australia for supporting his lab's work in this emerging research area (1057905, 1067289, 1105754, and IRIISS 9000220) and the Victorian Government Operational Infrastructure Support.