The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis
Claudia Guenther, Gui-Wei He, Andreas E Kremer, James M Murphy, Emma J Petrie, Kerstin Amann, Peter Vandenabeele, Andreas Linkermann, Christopher Poremba, Ulrike Schleicher, Christin Dewitz, Stefan Krautwald, Markus F Neurath, Christoph Becker, Stefan Wirtz
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2016
Awarded by DFG
Awarded by National Health and Medical Research Council of Australia
The authors thank C. Lindner, G. Fortsch, A. Taut, S. Wallmuller, H. Dorner, and V. Thonn for excellent technical assistance. We thank W. Alexander for providing the Mlkl<SUP>-/-</SUP> mice. We thank N. Takahashi and Y. Dondelinger for providing materials and S. Zopf for sampling of liver biopsies. We thank Sam Young for assistance with preparing recombinant protein expression constructs and bacmids. This research has received funding from DFG projects within SFB796, SPP1656, SFB1181-A08, project BE3686/2, KR4391/1-1, and the clinical research unit KFO257. Further support was given by the Interdisciplinary Center for Clinical Research of the University Erlangen-Nuremberg. JMM acknowledges support from the National Health and Medical Research Council of Australia (project 1057905, fellowship 1105754, and Independent Research Institute Infrastructure Support Scheme, 9000220) and the Victorian Government Operational Infrastructure Support Scheme. SK acknowledges support from Dr. Werner Jackstadt-Stiftung and Fresenius Medical Care Germany.