Comorbid Diabetes and Depression in a National Sample of Adults with Psychosis

Abstract

Objective People with psychosis have an elevated risk of depression and diabetes but no large-scale study has characterized their relationship. We aimed to assess this association and to evaluate possible explanatory factors. Methods Analysis of cross-sectional data from a national sample of 1155 people with psychosis who gave a fasting blood sample and could be tested for diabetes mellitus. The association between current diabetes mellitus and current depression was estimated using logistic regression, adjusted for age, sex and current psychotropic medication. Results A diagnosis of depression was significantly associated with diabetes (OR = 2.16, P =.048) and diabetes medication (OR = 2.50..