Journal article

Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso

BIOCONJUGATE CHEMISTRY | AMER CHEMICAL SOC | Published : 2017

Abstract

Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In this work, we produced poly(dopamine) (PDA) films with engineered patterns for improved cell adhesion. The patterned films were synthesized via the polymerization of dopamine at the air-water interface of a floating bed of spherical particles. Subsequent dissolution of the particles yielded free-standing PDA films with tunable geometrical patterns. Our results show that these patterned PDA films significantly enhance the adhesion of both cancer cells and stem cells, thus showing promise as substrates for cell attachment for various biomedical applications.

Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project no. CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030) and Super Science Fellowship (F.C., FS110200025) schemes. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We thank Biao Kong and Wei Zhu for helpful discussions. We thank Peggy Chan (Swinburne University) for generously providing the mesenchymal stem cells.