Journal article
The Intestinal Expulsion of the Roundworm Ascaris suum Is Associated with Eosinophils, Intra-Epithelial T Cells and Decreased Intestinal Transit Time
D Masure, T Wang, J Vlaminck, S Claerhoudt, K Chiers, W Van den Broeck, J Saunders, J Vercruysse, P Geldhof
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages. Due to the natural host-parasite relationship, pigs infected with A. suum make an excellent model to study the mechanisms of protection against this nematode. In pigs, a self-cure reaction eliminates most larvae from the small intestine between 14 and 21 days post infection. In this study, we investigated the mucosal immune response leading to the expulsion of A. suum and the contribution of the hepato-tracheal migration. Self-cure was independent of previous passage through..
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Funding Acknowledgements
This study was financed by the Agency for Innovation by Science and Technology (IWT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.