Journal article
Epithelial, metabolic and innate immunity transcriptomic signatures differentiating the rumen from other sheep and mammalian gastrointestinal tract tissues
R Xiang, VH Oddy, AL Archibald, PE Vercoe, BP Dalrymple
Peerj | PEERJ INC | Published : 2016
DOI: 10.7717/peerj.1762
Open access
Abstract
Background. Ruminants are successful herbivorous mammals, in part due to their specialized forestomachs, the rumen complex, which facilitates the conversion of feed to soluble nutrients by micro-organisms. Is the rumen complex a modified stomach expressing new epithelial (cornification) and metabolic programs, or a specialised stratified epithelium that has acquired new metabolic activities, potentially similar to those of the colon? How has the presence of the rumen affected other sections of the gastrointestinal tract (GIT) of ruminants compared to non-ruminants? Methods. Transcriptome data from 11 tissues covering the sheep GIT, two stratified epithelial and two control tissues, was analy..
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Awarded by University of Edinburgh
Funding Acknowledgements
This work was supported by the Department of Agriculture, Filling the Research Gap "International Coordination of the Rumen Pangenome project" FTRG-1194147-75. ALA and RT acknowledge support from BBSRC Institute Strategic Programme Grants. The Ensembl annotation was funded by BBSRC BB/I025328/1. Sequencing was carried out by Edinburgh Genomics, The University of Edinburgh. Edinburgh Genomics is partly supported through core grants from NERC (R8/H10/56), MRC (MR/K001744/1) and BBSRC (BB/J004243/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.