Journal article

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

M Doerflinger, W Forsyth, G Ebert, M Pellegrini, MJ Herold



Infectious diseases are a leading cause of death worldwide. Novel therapeutics are urgently required to treat multidrug-resistant organisms such as Mycobacterium tuberculosis and to mitigate morbidity and mortality caused by acute infections such as malaria and dengue fever virus as well as chronic infections such as human immunodeficiency virus-1 and hepatitis B virus. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, which has revolutionized biomedical research, holds great promise for the identification and validation of novel drug targets. Since its discovery as an adaptive immune system in prokaryotes, the CRISPR/Cas9 syste..

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Awarded by National Health and Medical Research Council Australia

Funding Acknowledgements

M. J. H. is supported by the National Health and Medical Research Council Australia (Project Grant GNT 1049720) and Cancer Council Victoria Venture Grant. M. P., M. D., G. E., and W. F. 's work is supported by National Health and Medical Research Council Australia (Grants 1006592, 1045549, and 1065626 to M. P.), the Sylvia and Charles Viertel Senior Medical Research Fellowship (M. P.), the CASS Foundation (G. E.), the Australian Centre for HIV and Hepatitis Virology Research (G. E.), the Victorian State Government Operational Infrastructure Support, and the Independent Research Institutes Infrastructure Support Scheme of the Australian Government National Health and Medical Research Council. The Walter and Eliza Hall Institute of Medical Research have a research license agreement with TetraLogic Pharmaceuticals (Malvern, PA, USA), the manufactures of the cIAP antagonist birinapant. Tetralogic has filed a PCT on behalf of the Walter and Eliza Hall Institute of Medical Research. M. P. provided consultative advice to, and was on the scientific advisory board of, TetraLogic Pharmaceuticals.