Single-nucleotide polymorphisms of genes involved in repair of oxidative DNA damage and the risk of recurrent depressive disorder

P Czarny; D Kwiatkowski; M Toma; P Gałecki; A Orzechowska; K Bobińska; A Bielecka-Kowalska; J Szemraj; M Berk; G Anderson; T Śliwiński

Journal article

Single-nucleotide polymorphisms of genes involved in repair of oxidative DNA damage and the risk of recurrent depressive disorder

P Czarny, D Kwiatkowski, M Toma, P Gałecki, A Orzechowska, K Bobińska, A Bielecka-Kowalska, J Szemraj, M Berk, G Anderson, T Śliwiński

Medical Science Monitor | INT SCIENTIFIC INFORMATION, INC | Published : 2016

DOI: 10.12659/MSM.898091

Abstract

Background: Depressive disorder, including recurrent type (rDD), is accompanied by increased oxidative stress and activation of inflammatory pathways, which may induce DNA damage. This thesis is supported by the presence of increased levels of DNA damage in depressed patients. Such DNA damage is repaired by the base excision repair (BER) pathway. BER efficiency may be influenced by polymorphisms in BER-related genes. Therefore, we genotyped nine single-nucleotide polymorphisms (SNPs) in six genes encoding BER proteins. Material/Methods: Using TaqMan, we selected and genotyped the following SNPs: c.-441G>A (rs174538) of FEN1, c.2285T>C (rs1136410) of PARP1, c.580C>T (rs1799782) and c.1196A>G ..

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University of Melbourne Researchers

Michael Berk Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported with funding from scientific research grants from the Polish National Science Centre (no. DEC-2014/13/N/NZ7/00232) and Medical University of Lodz (no. 503/5-139-01/503-51-008). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660)