Journal article
Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder
Piotr Czarny, Dominik Kwiatkowski, Monika Toma, Piotr Galecki, Agata Orzechowska, Kinga Bobinska, Anna Bielecka-Kowalska, Janusz Szemraj, Michael Berk, George Anderson, Tomasz Sliwinski
Medical Science Monitor: international medical journal for clinical and experimental research | INT SCIENTIFIC INFORMATION, INC | Published : 2016
DOI: 10.12659/MSM.898091
Abstract
BACKGROUND Depressive disorder, including recurrent type (rDD), is accompanied by increased oxidative stress and activation of inflammatory pathways, which may induce DNA damage. This thesis is supported by the presence of increased levels of DNA damage in depressed patients. Such DNA damage is repaired by the base excision repair (BER) pathway. BER efficiency may be influenced by polymorphisms in BER-related genes. Therefore, we genotyped nine single-nucleotide polymorphisms (SNPs) in six genes encoding BER proteins. MATERIAL AND METHODS Using TaqMan, we selected and genotyped the following SNPs: c.-441G>A (rs174538) of FEN1, c.2285T>C (rs1136410) of PARP1, c.580C>T (rs1799782) and c.1196A>..
View full abstractGrants
Awarded by Polish National Science Centre
Awarded by Medical University of Lodz
Awarded by NHMRC Senior Principal Research Fellowship
Funding Acknowledgements
This study was supported with funding from scientific research grants from the Polish National Science Centre (no. DEC-2014/13/N/NZ7/00232) and Medical University of Lodz (no. 503/5-139-01/503-51-008). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660)