Journal article

3D hybrid modelling of vascular network formation

Holger Perfahl, Barry D Hughes, Tomas Alarcon, Philip K Maini, Mark C Lloyd, Matthias Reuss, Helen M Byrne

JOURNAL OF THEORETICAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017

Abstract

We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The endothelial cells that comprise our vessel network are viewed as linearly elastic spheres that move in response to the forces they experience. We distinguish two types of endothelial cells: vessel elements are contained within the network and tip cells are located at the ends of vessels. Tip cells move in response to mechanical forces caused by interactions with neighbouring vessel elements and the local tissue environment, chemotactic forces and a persistence force which accounts for their tendency to continue moving in the..

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University of Melbourne Researchers

Grants

Awarded by Spanish Ministry of Economy (MINECO)


Awarded by Generalitat de Catalunya


Awarded by Moffitt PSOC NIH/NCI


Awarded by Australian Research Council


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This publication was based on work in part sponsored by the "Federal Ministry of Education and Research" Germany, funding initiative "e:Med" Systems Medicine (MultiscaleHCC) and funding initiative "e:bio" Systems Biology (PREDICT). T.A. gratefully acknowledges the Spanish Ministry of Economy (MINECO) for funding under grant MTM2015-71509-C2-1-R and Generalitat de Catalunya for funding under grant 2009SGR345. M.C.L. acknowledges funding from Moffitt PSOC NIH/NCI U54CA143970. B.D.H. acknowledges funding from the Australian Research Council (DP110100795).