Journal article

Analysis of enteroendocrine cell populations in the human colon

Patricia Martins, Josiane Fakhry, Enio Chaves de Oliveira, Billie Hunne, Linda J Fothergill, Mitchell Ringuet, Debora d'Avila Reis, Jens F Rehfeld, Brid Callaghan, John B Furness

CELL AND TISSUE RESEARCH | SPRINGER | Published : 2017

Abstract

Recent studies have shown that patterns of colocalisation of hormones in enteroendocrine cells are more complex than previously appreciated and that the patterns differ substantially between species. In this study, the human sigmoid colon is investigated by immunohistochemistry for the presence of gastrointestinal hormones and their colocalisation. The segments of colon were distant from the pathology that led to colectomy and appeared structurally normal. Only four hormones, 5-hydroxytryptamine (5-HT), glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and somatostatin, were common in enteroendocrine cells of the human colon. Cholecystokinin, present in the colon of some species, was absent,..

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