Journal article

Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice

Craig M Smith, Lesley L Walker, Tanawan Leeboonngam, Michael J McKinley, Derek A Denton, Andrew J Lawrence

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2016

Abstract

Due to the importance of dietary sodium and its paucity within many inland environments, terrestrial animals have evolved an instinctive sodium appetite that is commensurate with sodium deficiency. Despite a well-established role for central opioid signaling in sodium appetite, the endogenous influence of specific opioid receptor subtypes within distinct brain regions remains to be elucidated. Using selective pharmacological antagonists of opioid receptor subtypes, we reveal that endogenous mu-opioid receptor (MOR) signaling strongly drives sodium appetite in sodium-depleted mice, whereas a role for kappa (KOR) and delta (DOR) opioid receptor signaling was not detected, at least in sodium-de..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This research was supported by National Health and Medical Research Council of Australia Project Grant 1079891 (to A.J.L.) and Research Fellowship 1020737 (to A.J.L.), plus grants from the Pratt and Besen Family Foundations (to A.J.L.) and the Victorian Government Operational Infrastructure Support Programme. This research was also supported by grants from The Mathers Charitable Foundation of New York, The Search Foundation, Ms. Diana Gibson, Mr. S. Baillieu Myer, Dr. Mark Nelson, Mr. Robert Albert, Mrs. Jeanne Pratt, and Mr. Tim Jones.