Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities

P Sharma; S Dedeurwaerdere; MAD Vandenberg; K Fang; LA Johnston; SR Shultz; TJ O'Brien; KL Gilby

Journal article

Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities

P Sharma, S Dedeurwaerdere, MAD Vandenberg, K Fang, LA Johnston, SR Shultz, TJ O'Brien, KL Gilby

Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016

DOI: 10.1016/j.yebeh.2016.08.022

Abstract

Objective The neurobiological factors underlying a predisposition towards developing epilepsy and its common behavioral comorbidities are poorly understood. FAST rats are a strain that has been selectively bred for enhanced vulnerability to kindling, while the SLOW strain has been bred to be resistant to kindling. FAST rats also exhibit behavioral traits reminiscent of those observed in neurodevelopmental disorders (autism spectrum disorder (ASD)/attention-deficit/hyperactivity disorder (ADHD)) commonly comorbid with epilepsy. In this study, we aimed to investigate neuroanatomical differences between these strains that may be associated with a differential vulnerability towards these interre..

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University of Melbourne Researchers

Pragati Sharma Author

Leigh Johnston Author

Liam Johnson Author

Grants

Awarded by University of Melbourne

Funding Acknowledgements

This work was supported by the University of Melbourne Early Career Research Grant and FWO grant (G058612N) to Prof. Dr. Stefanie Dedeurwaerdere and the University of Melbourne Early Career Research Grant to Dr. Krista Gilby.