Journal article

Genotypic profiles of hepatitis B in African immigrants and their clinical relevance

Maria Christine Thurnheer, Rosalind Edwards, Thomas Ray Schulz, Lilly Yuen, Margaret Littlejohn, Peter Revill, Elizabeth Bannister, Melissa Chu, Firuz Tanyeri, Amanda Wade, Beverley-Ann Biggs, Joseph Sasadeusz

JOURNAL OF MEDICAL VIROLOGY | WILEY | Published : 2017

Abstract

Hepatitis B virus (HBV) from 40 adult African immigrants in Australia was characterized to determine the prevalence of different HBV genotypes and subgenotypes. A mutational analysis was then performed to determine the presence of clinically significant mutations and correlate them to clinical outcomes. Initial sequencing analysis revealed 13 with genotype A (32.5%), 13 with genotype D (32.5%), and 14 with genotype E (35%). Serology showed that 37 were HBeAg negative. Phylogenetic analysis identified a high prevalence (25%) of HBV subgenotype A1 in our cohort, a subgenotype which has been associated with more aggressive clinical disease. BCP/PC sequencing was obtained for 38 patients. BCP an..

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