Journal article

Effectiveness of individualized lung recruitment strategies at birth: an experimental study in preterm lambs

David G Tingay, Anushi Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele L Dellaca, Elizabeth J Perkins, Cornelis EE Zonneveld, Andy Adler, Don Black, Inez Frerichs, Anna Lavizzari, Magdy Sourial, Bartlomiej Grychtol, Fabio Mosca, Peter G Davis

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2017

Abstract

Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung while aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume response and a dynamic tidal positive end-expiratory pressure (PEEP) (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment maneuver (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration, and lung injury in 127 ± 1 day preterm lambs. Forty-eight fetal-instrumented lambs exposed to antenatal steroids were ventilated for 60 min after application of the allo..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study is supported by a National Health and Medical Research Council Project Grant (Grant ID 1009287) and the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia). D. Tingay is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (Grant ID 1053889). P. Davis is supported by a National Health and Medical Research Council Program Grant (Grant ID 606789). P. Davis is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant ID 556600).