Effect of colony-stimulating factors on the proteins synthesized by normal and leukemic myeloid progenitor cells.

Abstract

The proliferation and differentiation of normal granulocyte-macrophage (GM) progenitor cells is dependent on the presence of GM colony stimulating factor (GM-CSF). The proliferation of primary leukemic cells is also dependent on GMCSF, and some established myelomonocytic cell lines (e.g., WEHI3B D+) can be induced to differentiate by G-CSF.