Journal article
MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage
NTT Thuong, TTB Tram, TD Dinh, PVK Thai, D Heemskerk, ND Bang, TTH Chau, DG Russell, GE Thwaites, TR Hawn, M Caws, SJ Dunstan
Genes and Immunity | NATURE PUBLISHING GROUP | Published : 2016
DOI: 10.1038/gene.2016.43
Open access
Abstract
Macrophage receptor with collagenous structure (MARCO) has an important role in the phagocytosis of Mycobacterium tuberculosis (M. tuberculosis). We hypothesized that MARCO polymorphisms are associated with phagocytosis, tuberculosis (TB) disease susceptibility and presentation, and infecting lineage. We used a human cellular model to examine how MARCO genotype mediates the immune response; a case-control study to investigate tuberculosis host genetic susceptibility; and a host-pathogen genetic analysis to study host-pathogen interactions. Two MARCO heterozygous (AG) genotypes (single-nucleotide polymorphisms rs2278589 and rs6751745) were associated with impaired phagocytosis of M. tuberculo..
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Awarded by Wellcome Trust Training Fellowship in Public Health and Tropical Medicine
Awarded by Wellcome Trust
Funding Acknowledgements
We acknowledge the work of the clinical and laboratory staff from the Hospital of Tropical Diseases, Pham Ngoc Thach Hospital and the District TB units in HCMC who initially diagnosed and studied the patients with TBM and PTB. We would like to thank Dr Nguyen Thi Hieu from Hung Vuong Obstetric Hospital and all Vietnamese individuals who were recruited into this study. This work was supported by a Wellcome Trust Training Fellowship in Public Health and Tropical Medicine awarded to NTTT (097124/Z/11/Z).